Diabetologia. 2013 Apr;56(4):856-66. doi: 10.1007/s00125-012-2824-6. Epub 2013 Jan 26.
Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin.
Wakae-Takada N, Xuan S, Watanabe K, Meda P, Leibel RL.
http://www.ncbi.nlm.nih.gov/pubmed/23354125
Diabetologia. 2013 May;56(5):1047-56. doi: 10.1007/s00125-013-2847-7. Epub 2013 Feb 13.
Species-specific vesicular monoamine transporter 2 (VMAT2) expression in mammalian pancreatic beta cells: implications for optimising radioligand-based human beta cell mass (BCM) imaging in animal models.
Schäfer MK, Hartwig NR, Kalmbach N, Klietz M, Anlauf M, Eiden LE, Weihe E.
http://www.ncbi.nlm.nih.gov/pubmed/23404442
Autophagy. 2013 Apr 1;9(4):550-67. doi: 10.4161/auto.23662. Epub 2013 Feb 4.
Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters.
Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Féraille E, Brown D, Hasler U.
http://www.ncbi.nlm.nih.gov/pubmed/23380587
J Vasc Surg. 2013 Jan 23. pii: S0741-5214(12)02028-9. doi: 10.1016/j.jvs.2012.09.041. [Epub ahead of print]
Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins.
Berard X, Déglise S, Alonso F, Saucy F, Meda P, Bordenave L, Corpataux JM, Haefliger JA.
http://www.ncbi.nlm.nih.gov/pubmed/23351647
Diabetes Res Clin Pract. 2013 Mar;99(3):250-9. doi: 10.1016/j.diabres.2012.10.016. Epub 2012 Nov 20.
Connexins and β-cell functions.
Cigliola V, Chellakudam V, Arabieter W, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/23176806
PLoS One. 2012;7(11):e50131. doi: 10.1371/journal.pone.0050131. Epub 2012 Nov 16.
Early metabolic defects in dexamethasone-exposed and undernourished intrauterine growth restricted rats.
Somm E, Vauthay DM, Guérardel A, Toulotte A, Cettour-Rose P, Klee P, Meda P, Aubert ML, Hüppi PS, Schwitzgebel VM.
http://www.ncbi.nlm.nih.gov/pubmed/23166830
PLoS One. 2012;7(9):e45844. doi: 10.1371/journal.pone.0045844. Epub 2012 Sep 20.
Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.
Martin D, Allagnat F, Gesina E, Caille D, Gjinovci A, Waeber G, Meda P, Haefliger JA.
http://www.ncbi.nlm.nih.gov/pubmed/23029270
Biochim Biophys Acta. 2012 Aug;1818(8):1919-36. doi: 10.1016/j.bbamem.2011.09.022. Epub 2011 Oct 1.
Connexin-dependent signaling in neuro-hormonal systems.
Potolicchio I, Cigliola V, Velazquez-Garcia S, Klee P, Valjevac A, Kapic D, Cosovic E, Lepara O, Hadzovic-Dzuvo A, Mornjacovic Z, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/22001400
PLoS One. 2012;7(7):e41535. doi: 10.1371/journal.pone.0041535. Epub 2012 Jul 25.
The intercellular synchronization of Ca2+ oscillations evaluates Cx36-dependent coupling.
Bavamian S, Pontes H, Cancela J, Charollais A, Startchik S, Van de Ville D, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/22848521
Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E144-51. doi: 10.1152/ajpendo.00489.2011. Epub 2012 May 8.
Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice.
Carvalho CP, Oliveira RB, Britan A, Santos-Silva JC, Boschero AC, Meda P, Collares-Buzato CB.
http://www.ncbi.nlm.nih.gov/pubmed/22569071
Diabetes. 2012 Jul;61(7):1656-8. doi: 10.2337/db12-0336.
The in vivo β-to-β-cell chat room: connexin connections matter.
Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/22723271
J Membr Biol. 2012 Jun;245(5-6):263-73. doi: 10.1007/s00232-012-9447-1. Epub 2012 Jun 23.
Cx36 is a target of Beta2/NeuroD1, which associates with prenatal differentiation of insulin-producing β cells.
Nlend RN, Aït-Lounis A, Allagnat F, Cigliola V, Charollais A, Reith W, Haefliger JA, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/22729650
Diabetologia. 2012 May;55(5):1247-57. doi: 10.1007/s00125-012-2491-7. Epub 2012 Feb 23.
Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis.
Andralojc K, Srinivas M, Brom M, Joosten L, de Vries IJ, Eizirik DL, Boerman OC, Meda P, Gotthardt M.
http://www.ncbi.nlm.nih.gov/pubmed/22358499
Islets. 2012 May-Jun;4(3):243-8. doi: 10.4161/isl.20857. Epub 2012 May 1.
Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients.
Botsikas D, Terraz S, Vinet L, Lamprianou S, Becker CD, Bosco D, Meda P, Montet X.
http://www.ncbi.nlm.nih.gov/pubmed/22722479
PLoS Genet. 2012;8(3):e1002552. doi: 10.1371/journal.pgen.1002552. Epub 2012 Mar 8.
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.
Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M.
http://www.ncbi.nlm.nih.gov/pubmed/22412385
Contrast Media Mol Imaging. 2012 Mar-Apr;7(2):160-6. doi: 10.1002/cmmi.475.
Radiolabelled GLP-1 analogues for in vivo targeting of insulinomas.
Brom M, Joosten L, Oyen WJ, Gotthardt M, Boerman OC.
http://www.ncbi.nlm.nih.gov/pubmed/22434628
Stem Cells Transl Med. 2012 Mar;1(3):248-60. doi: 10.5966/sctm.2011-0028. Epub 2012 Mar 7.
Embryonic stem cell-based cardiopatches improve cardiac function in infarcted rats.
Vallée JP, Hauwel M, Lepetit-Coiffé M, Bei W, Montet-Abou K, Meda P, Gardier S, Zammaretti P, Kraehenbuehl TP, Herrmann F, Hubbell JA, Jaconi ME.
http://www.ncbi.nlm.nih.gov/pubmed/23197784
Eur J Nucl Med Mol Imaging. 2012 Mar;39(3):461-2. doi: 10.1007/s00259-011-2020-9.
18F-Labelled exendin to image GLP-1 receptor-expressing tissues: from niche to blockbuster?
Boerman OC, Gotthardt M.
http://www.ncbi.nlm.nih.gov/pubmed/22170323
Imaging in Medicine; February 2012, Vol. 4, No. 1, Pages 17-23 , DOI 10.2217/iim.11.76
Annual Congress of the European Association of Nuclear Medicine
Paolo Meda
http://www.futuremedicine.com/doi/pdf/10.2217/iim.11.76
EJNMMI Res. 2012 Jan 27;2:4. doi: 10.1186/2191-219X-2-4.
Improved labelling of DTPA- and DOTA-conjugated peptides and antibodies with 111In in HEPES and MES buffer.
Brom M, Joosten L, Oyen WJ, Gotthardt M, Boerman OC.
http://www.ncbi.nlm.nih.gov/pubmed/22284727
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20719-24. doi: 10.1073/pnas.1109480108. Epub 2011 Dec 5.
Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands.
Virostko J, Henske J, Vinet L, Lamprianou S, Dai C, Radhika A, Baldwin RM, Ansari MS, Hefti F, Skovronsky D, Kung HF, Herrera PL, Peterson TE, Meda P, Powers AC.
http://www.ncbi.nlm.nih.gov/pubmed/22143775
J Clin Invest. 2011 Dec;121(12):4870-9. doi: 10.1172/JCI40509. Epub 2011 Nov 7.
Connexins protect mouse pancreatic β cells against apoptosis.
Klee P, Allagnat F, Pontes H, Cederroth M, Charollais A, Caille D, Britan A, Haefliger JA, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/22056383
Diabetes. 2011 Nov;60(11):2853-60. doi: 10.2337/db11-0726. Epub 2011 Sep 16.
High-resolution magnetic resonance imaging quantitatively detects individual pancreatic islets.
Lamprianou S, Immonen R, Nabuurs C, Gjinovci A, Vinet L, Montet XC, Gruetter R, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/21926272
Physiol Rev. 2011 Oct;91(4):1393-445. doi: 10.1152/physrev.00027.2010.
Connexins: key mediators of endocrine function.
Bosco D, Haefliger JA, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/22013215
PLoS One. 2011;6(9):e25178. doi: 10.1371/journal.pone.0025178. Epub 2011 Sep 16.
Targeting pannexin1 improves seizure outcome.
Santiago MF, Veliskova J, Patel NK, Lutz SE, Caille D, Charollais A, Meda P, Scemes E.
http://www.ncbi.nlm.nih.gov/pubmed/21949881
Pediatr Res. 2011 Aug;70(2):142-7. doi: 10.1038/pr.2011.367.
Connexin implication in the control of the murine beta-cell mass.
Klee P, Lamprianou S, Charollais A, Caille D, Sarro R, Cederroth M, Haefliger JA, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/21527868
Nat Immunol. 2011 Jun 26;12(8):761-9. doi: 10.1038/ni.2062.
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.
Woodfin A, Voisin MB, Beyrau M, Colom B, Caille D, Diapouli FM, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA, Nourshargh S.
http://www.ncbi.nlm.nih.gov/pubmed/21706006
Diabetes. 2011 Jun;60(6):1705-15. doi: 10.2337/db10-1102. Epub 2011 Apr 26.
In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.
Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR.
http://www.ncbi.nlm.nih.gov/pubmed/21521872
Inorg Chem. 2011 May 16;50(10):4260-71. doi: 10.1021/ic101775q. Epub 2011 Apr 13.
Isomerism of [64Cu-NOTA-Bn]-labeled radiotracers: separation of two complex isomers and determination of their interconversion energy barrier using ion pair chromatography.
Schlesinger J, Rajander J, Ihalainen JA, Ramesh D, Eklund P, Fagerholm V, Nuutila P, Solin O.
http://www.ncbi.nlm.nih.gov/pubmed/21488661
Mol Imaging. 2011 Apr;10(2):144-52.
Preclinical evaluation of 68Ga-DOTA-minigastrin for the detection of cholecystokinin-2/gastrin receptor-positive tumors.
Brom M, Joosten L, Laverman P, Oyen WJ, Béhé M, Gotthardt M, Boerman OC.
http://www.ncbi.nlm.nih.gov/pubmed/21439259
Diabetes. 2011 Feb;60(2):381-2. doi: 10.2337/db10-1591.
A therapeutic insight in beta-cell imaging?
Gotthardt M.
http://www.ncbi.nlm.nih.gov/pubmed/21270250
Cell Transplant. 2010;19(12):1573-85. doi: 10.3727/096368910X515863. Epub 2010 Aug 17.
Assessment of human islet labeling with clinical grade iron nanoparticles prior to transplantation for graft monitoring by MRI.
Ris F, Lepetit-Coiffe M, Meda P, Crowe LA, Toso C, Armanet M, Niclauss N, Parnaud G, Giovannoni L, Bosco D, Morel P, Vallee JP, Berney T.
http://www.ncbi.nlm.nih.gov/pubmed/20719068
Curr Pharm Des. 2010 May;16(14):1595-608.
Towards high resolution optical imaging of beta cells in vivo.
Villiger M, Goulley J, Martin-Williams EJ, Grapin-Botton A, Lasser T.
http://www.ncbi.nlm.nih.gov/pubmed/20146662
Diabetologia. 2010 Oct;53(10):2089-92. doi: 10.1007/s00125-010-1848-z. Epub 2010 Jul 10.
Beta cell adaptation in pregnancy: a major difference between humans and rodents?
Genevay M, Pontes H, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/20623217
Cell. 2010 Sep 17;142(6):889-901. doi: 10.1016/j.cell.2010.08.017.
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization.
Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basañez G, Meda P, Martinou JC.
http://www.ncbi.nlm.nih.gov/pubmed/20850011
J Nucl Med. 2010 Sep;51(9):1439-46. doi: 10.2967/jnumed.109.074492. Epub 2010 Aug 18.
Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas.
Fagerholm V, Mikkola KK, Ishizu T, Arponen E, Kauhanen S, Någren K, Solin O, Nuutila P, Haaparanta M.
http://www.ncbi.nlm.nih.gov/pubmed/20720057
Diabetologia. September 2010, Volume 53, Issue 1 Supplement, S195-6
Vesicular monoamine transporter 2 gene expression in beta cells of primates but not of rodents: implications for developing radioligands for imaging of beta cell mass in animal models
Schafer MK, Eiden L, Weihe E
http://link.springer.com/article/10.1007%2Fs00125-010-1872-z
Cardiovasc Res. 2010 Jul 1;87(1):166-76. doi: 10.1093/cvr/cvq031. Epub 2010 Jan 28.
An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension.
Alonso F, Krattinger N, Mazzolai L, Simon A, Waeber G, Meda P, Haefliger JA.
http://www.ncbi.nlm.nih.gov/pubmed/20110337
Diabetologia. 2010 Jul;53(7):1372-83. doi: 10.1007/s00125-010-1714-z. Epub 2010 Apr 9.
A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker.
Flamez D, Roland I, Berton A, Kutlu B, Dufrane D, Beckers MC, De Waele E, Rooman I, Bouwens L, Clark A, Lonneux M, Jamar JF, Goldman S, Maréchal D, Goodman N, Gianello P, Van Huffel C, Salmon I, Eizirik DL.
http://www.ncbi.nlm.nih.gov/pubmed/20379810
Diabetologia. 2010 Jul;53(7):1428-37. doi: 10.1007/s00125-010-1726-8. Epub 2010 Apr 2.
Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets.
Carvalho CP, Barbosa HC, Britan A, Santos-Silva JC, Boschero AC, Meda P, Collares-Buzato CB.
http://www.ncbi.nlm.nih.gov/pubmed/20361177
Diabetes. 2010 Jul;59(7):1674-85. doi: 10.2337/db09-0986. Epub 2010 Apr 22.
The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.
Ait-Lounis A, Bonal C, Seguín-Estévez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W.
http://www.ncbi.nlm.nih.gov/pubmed/20413507
Eur J Nucl Med Mol Imaging. 2010 Jul;37(7):1345-55. doi: 10.1007/s00259-009-1363-y. Epub 2010 Jan 29.
68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET.
Brom M, Oyen WJ, Joosten L, Gotthardt M, Boerman OC.
http://www.ncbi.nlm.nih.gov/pubmed/20111963
Curr Pharm Des. 2010 May;16(14):1545-6.
Beta cell imaging--why we need it and what has been achieved.
Gotthardt M.
http://www.ncbi.nlm.nih.gov/pubmed/20377520
Curr Pharm Des. 2010 May;16(14):1609-18.
Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach.
Bouckenooghe T, Flamez D, Ortis F, Goldman S, Eizirik DL.
http://www.ncbi.nlm.nih.gov/pubmed/20146665
Curr Pharm Des. 2010 May;16(14):1561-7.
Development of radiotracers for the determination of the beta-cell mass in vivo.
Brom M, Andrałojć K, Oyen WJ, Boerman OC, Gotthardt M.
http://www.ncbi.nlm.nih.gov/pubmed/20146667
Diabetes. 2010 Apr;59(4):978-86. doi: 10.2337/db09-0881. Epub 2010 Jan 19.
Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells.
Roggli E, Britan A, Gattesco S, Lin-Marq N, Abderrahmani A, Meda P, Regazzi R.
http://www.ncbi.nlm.nih.gov/pubmed/20086228
Adv Exp Med Biol. 2010;654:39-57. doi: 10.1007/978-90-481-3271-3_3.
Approaches for imaging islets: recent advances and future prospects.
Ahlgren U, Gotthardt M.
http://www.ncbi.nlm.nih.gov/pubmed/20217493
Hum Mol Genet. 2010 Jan 15;19(2):262-75. doi: 10.1093/hmg/ddp490. Epub 2009 Oct 28.
Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins.
del Castillo FJ, Cohen-Salmon M, Charollais A, Caille D, Lampe PD, Chavrier P, Meda P, Petit C.
http://www.ncbi.nlm.nih.gov/pubmed/19864490
Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1509-15. doi: 10.1161/ATVBAHA.109.187559. Epub 2009 Jul 2.
Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.
Scheiermann C, Colom B, Meda P, Patel NS, Voisin MB, Marrelli A, Woodfin A, Pitzalis C, Thiemermann C, Aurrand-Lions M, Imhof BA, Nourshargh S.
http://www.ncbi.nlm.nih.gov/pubmed/19574560
Diabetologia. 2009 Aug;52(8):1599-607. doi: 10.1007/s00125-009-1383-y. Epub 2009 May 30.
In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy.
Villiger M, Goulley J, Friedrich M, Grapin-Botton A, Meda P, Lasser T, Leitgeb RA.
http://www.ncbi.nlm.nih.gov/pubmed/19484218
Journal of Labelled Compounds and Radiopharmaceuticals, 2009, 52(S1):72
Radiosynthesis of [64Cu((S)-P-Maleimidobenzyl-NOTA)] - and preparation of high effective specific activity [64Cu]-MAN-EXENDIN-4(9-39) via site-specific prelabelling
J. Schlesinger*, J. Rajander, M. A. Avila-Rodriguez, V. Fagerholm, P. Nuutila and O. Solin
http://onlinelibrary.wiley.com/doi/10.1002/jlcr.1632/abstract
Journal of Labelled Compounds and Radiopharmaceuticals, 2009, 52(S1):234
Increasing specific activity in Cu-64 production by reprocessing the Ni-64 target material
J. Rajander, J. Schlesinger, M. A. Avila-Rodriguez and O. Solin
http://onlinelibrary.wiley.com/doi/10.1002/jlcr.1643/abstract
Am J Physiol Endocrinol Metab. 2009 May;296(5):E1120-32. doi: 10.1152/ajpendo.90592.2008. Epub 2009 Feb 10.
The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue.
Veyrat-Durebex C, Montet X, Vinciguerra M, Gjinovci A, Meda P, Foti M, Rohner-Jeanrenaud F.
http://www.ncbi.nlm.nih.gov/pubmed/19208855
Hum Mol Genet. 2009 Feb 1;18(3):428-39. doi: 10.1093/hmg/ddn370. Epub 2008 Nov 10.
Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.
Serre-Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, Gauthier BR, Diaferia GR, Giepmans BN, Lupi R, Marchetti P, Deng S, Buhler L, Berney T, Cirulli V, Meda P.
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19000992/
Curr Protein Pept Sci. 2009 Feb;10(1):18-29.
Connexins, diabetes and the metabolic syndrome.
Hamelin R, Allagnat F, Haefliger JA, Meda P.
http://www.ncbi.nlm.nih.gov/pubmed/19275669
Cell. 2009 Jan 23;136(2):235-48. doi: 10.1016/j.cell.2008.11.018. Epub 2009 Jan 8.
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R.
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19135240/
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